On Catalina, I saw that were some issues with samtools. < La ofensiva de los exmédicos de la clínica Sierra Bella que podría anular polémico negocio > por Catalina Batarce latercera 1marzo2023.

So, my question is really if you heard of any specific issues in installing various bioinformatics tools on Big Sur.

In any case, I wouldn't like to solve java installation issues for instance by upgrading to Big Sur and not be able to install instead others bioinformatics tools. In case you don’t know the process follow these instructions. Might be easier to install on Big Sur? Besides, I also get the message that macOS HS is not supported by mac anymore, which in time might become a problem. Command - R: Install the latest macOS that was installed on your Mac. I get Error: A JNI error has occurred, please check your installation and try again Now I have problems installing java for GATK4 installation. However, it was a headache to install for instance MySQL (not bioinformatics related) on HS, and I understood that it would have been much easier to do this on Catalina and I assume Big Sur as well. So far on High Sierra, I was able to install without problems by using either conda either brew main bioinformatics tools as samtools, picard, bcftools, pangolin, etc. Using the method below, you will be able to upgrade to the latest macOS that is compatible with your Mac.

Sierra to catalina